#Immune repertoire capture standfod drivers#

Overlap and effective size of the human CD8 + T cell receptor repertoire. Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells. Study of the T-cell receptor repertoire by CDR3 spectratyping. Quantitative flow cytometry for the analysis of T cell receptor V β chain expression. Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: comparison with oligonucleotide‐driven amplification for evaluation of V β expression. Size estimate of the αβ TCR repertoire of naive mouse splenocytes. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. The past, present, and future of immune repertoire biology-the rise of next-generation repertoire analysis. Rep-Seq: uncovering the immunological repertoire through next-generation sequencing. New perspectives for large-scale repertoire analysis of immune receptors. Clonal replacement of tumor-specific T cells following PD-1 blockade.

Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. This study describes the capture of paired TCRαβ and targeted gene expression in single cells.Īzizi, E. Linking T-cell receptor sequence to functional phenotype at the single-cell level. Tumor and microenvironment evolution during immunotherapy with nivolumab. Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients.

#Immune repertoire capture standfod drivers#

Understanding the drivers of MHC restriction of T cell receptors. Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins. Diversity and clonal selection in the human T-cell repertoire. A direct estimate of the human αβ T cell receptor diversity. Using T cell receptor repertoires to understand the principles of adaptive immune recognition. The many important facets of T-cell repertoire diversity. The T cell receptor genes and T cell recognition.